Research

Project 1

Application of tissue-specific stem/progenitor cells for osteoarthritis

ITC -Health@InnoHK -The Center for Neuromusculoskeletal Restorative Medicine (CNRM), co-PI, 2022 to 2027, ITC.  https://www.cnrm.com.hk/

       

Use mouse model to study osteoarthritis progression. This is a u CT reconstruction picture to show the bone changes of mice knees in healthy and OA joints. White arrows show the disease changes in osteoarthritic knee joints. (Credit: Jiang Lab RM, http://jianglabrm.com)

• Bioact Mater. 25:256-272 (2023)
• Stem Cell Res Ther, 14:160 (2023)
• PLoS ONE,18(10): e0286626 (2023)
• Adv Sci (Weinh), 23: e22601 (2026)
• Eur Cell Mater, 56, 34–47 (2026)

Project 2

Meniscus Regeneration via Activation of Human Tissue Resident Stem Progenitor Cells

RGC – General Research Fund, No.14104022, 2023 to 2026.

(Credit: Jiang Lab RM, http://jianglabrm.com)

• Bioact Mater. 25:256-272 (2023)

Project 3

Grancalcin+ Immune Cells in Osteoarthritis: Cellular and Molecular Targets for Future Intervention

NSFC/RGC Joint Research Scheme, NSFC/RGC: N_CUHK483/22, UGC, Hong Kong SAR, 2023-2027

• PLoS ONE, 18(10): e0286626 (2023)
• Bone Res, Jan 25;12(1):6 (2024)
• Science bulletin, 69(12), 1964–1979 (2024)
• Bioactive materials, 36, 508–523. (2024)
• Bioactive materials 39, 255-272 (2024)
• Nature Aging 4 (11), 1562-1581 (2024)
• J Adv Res. 79:179-195. (2026)
• Advanced Science, e22601 (2026)
• Eur. Cell. Mater. 56, 34-47 (2026)

Project 4

Development of a Small Molecular Tool for Regulating NGF/TrkA Signalling and Bone Regeneration

RGC – Early Career Scheme, No. 24123625, UGC, Hong Kong SAR, 2026-2028.

 

 

 

 

 

 

 

 

(Credit: Jiang Lab RM, http://jianglabrm.com)

Completed

Project 1

Stem Cells and Translational Medicine

Ministry of Science and Technology (MOST) of China, National Key R&D Program of China, Young Scientist Scheme, 2019YFA0111900, 2019 to 2023.

Tissue Specific Stem/Progenitor Cells in Cartilage Regeneration J Ortho Transl, 2(2):56-65 (2014) Stem Cells Transl Med, 5(6): 733–44(2016) Bioact Mater. 25:256-272 (2023) Stem Cell Res Ther, 14:160 (2023) Am J Sports Med; 51(2):461-475 (2023) Bone Res. 25;12(1):6 (2024)

Disease Activated Stem/Progenitor Cells in Osteoarthritis Nature Reviews Rheumatology, 11(4):206-12 (2015) Arthritis Research & Therapy, 17;17:327 (2015) Osteoarthritis and Cartilage, 25(1), 138-145 (2017) The FASEB Journal, 33(9):10231-10239 (2019) Frontin Cell &Dev Biol (2021) Science Bulletin, 30;69(12):1964-1979 (2024) Bioact Mater. 39:255-272 (2024) Bioact Mater. 4; 36:508-523 (2024) Nature Aging, 4(11):1562-1581 (2024) Adv Sci (Weinh), 23: e22601 (2026) Eur Cell Mater, 56, 34–47 (2026)

Research Interests and Expertise in

• Tissue Engineering and Regenerative Medicine
• Cartilage and Bone Repair and Regeneration
• Adult Tissue Specific Stem/Progenitor Cells
• Regulating Stem Cells for Cell-based Therapy
• Regulators of Stem Cell Aging
• Mechanism of Osteoarthritis and Other Degenerative and Inflammatory Diseases
• Bioproducts for Cell-based Therapy
• From Bench to Bedside and to the Bench – the Pathway of Translational Medicine

awards and Honours since 2018

Prof. Jiang Gold Medal, awarded by The 51st International Exhibition of Inventions Geneva (IEIG), Switzerland, 03/2026 1st Prize , Zhejiang Science and Technology Progress Award, awarded by The People’s Government of Zhejiang, China, 11/2023 National Key Research and Development (R&D) Program, Young Scientist Scheme, awarded by Ministry of Science and Technology (MOST) of China, China, 11/2019 2nd Prize, COA Orthopaedics Youth Research Award, Chinese Medical Association, Chinese Orthopaedic Association, awarded by The 13th Annual Congress of Chinese Orthopaedic Association, China, 11/2018

Lab staff and students Dr. ZHU Xiaobo (Former PhD student), Dr. LI Kejia (Postdoctoral Fellow), Gold Medal, awarded by The 51st International Exhibition of Inventions Geneva (IEIG), Switzerland, 03/2026 Dr. LI Xiao (Postdoctoral Fellow), Prof. Jiang Yangzi, Best Poster Presentation Award, awarded by Nature Conference Translational Biomaterials, 01/2026 Dr. LI Xiao, Postdoctoral Fellow, The Innovation and Technology Commission of Hong Kong Grants, funded by International Society for Stem Cell Research, 06/2025 YANG Sichen, PhD candidate, The Innovation and Technology Commission of Hong Kong Grants, funded by International Society for Stem Cell Research, 06/2025 Dr. LI Xiao, Postdoctoral Fellow, Research Talent Hub (RTH), funded by the Innovation and Technology Commission (ITC), Hong Kong SAR Government, 12/2024–12/2025 Dr. SUN Jing, Former PhD student and Postdoctoral Fellow, Research Talent Hub (RTH), funded by the Innovation and Technology Commission (ITC), Hong Kong SAR Government, 11/2023–11/2024 Dr. LI Xiao, Postdoctoral Fellow, Best Poster Presentation Award, awarded by Tissue Engineering and Regenerative Medicine International Society Asia-Pacific Chapter Conference (TERMIS-AP), 10/2023 Dr. SUN Jing, Former PhD student and Postdoctoral Fellow, Impact Postdoctoral Fellowship Scheme, awarded by The Chinese University of Hong Kong (CUHK), 2021–2023

Supported by

• The Chinese University of Hong Kong
• Ministry of Science and Technology (MOST) of China, National Key R&D Program of China
• Innovation and Technology Commission, Health@InnoHK, Hong Kong SAR, China
• University Grants Committee, Hong Kong SAR, China
• National Natural Science Foundation of China