JIANG Lab & Research Group

Publication

Journal Papers

2024

  1. Deng K, Hua Y, Gao Y, Zheng H, Jiang Y, Wang Y, Gao C, Ren T, Zhu Y. Thermosensitive Hydrogel with Programmable, Self-Regulated HIF-1α Stabilizer Release for Myocardial Infarction Treatment. Adv Sci. 2024 Sep 23:e2408013. [doi: 10.1002/advs.202408013]
  2. Hou J, Chen K, He C, Li X, Huang M, Jiang Y, Jiao Y, Xiao Q, He W, Liu L, Zou N, Huang M, Wei J, Xiao Y, Yang M, Luo X, Zeng C*, Lei G*, Li C*. Aged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence. Nat Aging. 2024 Sep 12. [doi: 10.1038/s43587-024-00694-0]
  3. He C, Hu C, He W, Sun Y, Jiang Y, Liu L, Hou J, Chen K, Jiao R, Huang M, Huang M, Yang M, Lu Q, Wei J, Zeng C, Lei G, Li C*. Macrophage-derived extracellular vesicles regulate skeletal stem/progenitor Cell lineage fate and bone deterioration in obesity. Bioact Mater., June;36:508-523 (2024) [doi: https://doi.org/10.1016/j.bioactmat.2024.06.035]
  4. Huang, M., Zhou, J., Li, X., Liu, R., Jiang, Y., Chen, K., Jiao, Y., Yin, X., Liu, L., Sun, Y., Wang, W., Xiao, Y., Su, T., Guo, Q., Huang, Y., Yang, M., Wei, J., Quarles, L.D., Xiao, Z., Zeng, C., Luo, X., Lei, G., Li, C.* (2024). Mechanical protein polycystin-1 directly regulates osteoclastogenesis and bone resorption. Science Bulletin, Jun 30;69(12):1964-1979 (2024). [doi: 10.1016/j.scib.2024.04.044]
  5. Zhu X, Cao M, Li K, Chan YT, Chan HF, Mak YW, Yao H, Sun J, Ong MTY, Ho KKW, Lee CW, Lee OKS, Yung PHS, Jiang Y*. “Intra-articular sustained-release of pirfenidone as a disease-modifying treatment for early osteoarthritis.” Bioact Mater., Sep;39:255-272(2024). [doi: 10.1016/j.bioactmat.2024.05.028]
  6. Zou NY, Liu R, Huang M, Jiao YR, Wei J, Jiang Y, He WZ, Huang M, Xu YL, Liu L, Sun YC, Yang M, Guo Q, Huang Y, Su T, Xiao Y, Wang WS, Zeng C, Lei GH, Luo XH*, Li CJ*. “Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing.” Bone Res. Jan 25;12(1):6 (2024). [doi: 10.1038/s41413-023-00309-1]

2023

  1. Jiang Y*, Tuan RS*. “Bioactivity of human adult stem cells and functional relevance of stem cell-derived extracellular matrix in chondrogenesis”. Stem Cell Res Ther. 14, 160 (2023). [doi: 10.1186/s13287-023-03392-7]
  2. Li X, Chan YT, Jiang Y*. “Development of an image processing software for quantification of histological calcification staining images”. PLoS ONE 18(10): e0286626. (2023). [doi: 10.1371/journal.pone.0286626]
  3. Sun J#, Chan YT, Ho KWK, Zhang L, Bian L, Tuan RS*, Jiang Y#*. “Slow walk” mimetic tensile loading maintains human meniscus tissue resident progenitor cells homeostasis in photocrosslinked gelatin hydrogel. Bioact Mater. 25:256-272, Feb 8 (2023). [doi: 10.1016/j.bioactmat.2023.01.025]
  4. Cao M, Yao S, Zhu X, Ong MTY, Yung PSH*, Jiang Y*. Doxycycline Promotes Graft Healing and Attenuates Posttraumatic Osteoarthritis After Anterior Cruciate Ligament Reconstruction in a Rat Model. Am J Sports Med. Feb 51(2):461-475(2023). [doi: 10.1177/03635465221145015]

2022

  1. Shao JF, Jiang Y, Fang ZY*. “Editorial: Single cell intelligence and tissue engineering.” Front. Bioeng. Biotechnol., 10:1019929(2022). [doi: 10.3389/fbioe.2022.1019929]
  2. He WZ, Yang M, Jiang Y, He C, Sun YC, Liu L, Huang M, Jiao YR, Chen KX, Hou J, Huang M, Xu YL, Feng X, Liu Y, Guo Q, Peng H, Huang Y, Su T, Xiao Y, Li Y, Zeng C, Lei G, Luo XH, Li CJ. “miR-188-3p targets skeletal endothelium coupling of angiogenesis and osteogenesis during ageing. ” Cell Death Dis 13, 494 (2022). [doi: 10.1038/s41419-022-04902-w]
  3. Li K, Fan L, Lin J, Heng BC, Deng Z, Zheng Q, Zhang J, Jiang Y*, Ge Z*. “Nanosecond pulsed electric fields prime mesenchymal stem cells to peptide ghrelin and enhance chondrogenesis and osteochondral defect repair in vivo. ” Sci China Life Sci, 65(5):927-939(2022). [doi: 10.1007/s11427-021-1983-y]
  4. Cao M, Ong MTY, Yung PSH, Tuan RS, Jiang Y*. “Role of synovial lymphatic function in osteoarthritis. ” Osteoarthritis Cartilage, S1063-4584(22)00719-1(2022). [doi: 10.1016/j.joca.2022.04.003]
  5. Yang J, Zhang X, Chen J, Heng BC, Jiang Y, Hu X*, & Ge Z*. “Macrophages promote cartilage regeneration in a time‐ and phenotype‐dependent manner. ” Journal of Cellular Physiology, (2022).  [doi: 10.1002/jcp.30694]
  6. Jiang Y*.” Osteoarthritis Year in Review 2021: Biology.”Osteoarthritis and Cartilage, (2022).  [doi: 10.1016/j.joca.2021.11.009]

2021

  1. Zhu X, Lee C, Xu H, Wang Y, Yung SH, Jiang Y, Lee OK*. “Phenotypic Alteration of Macrophages During Osteoarthritis: A Systematic Review.” Arthritis Research & Therapy, (2021). [doi:10.1186/s13075-021-02457-3]
  2. Li K, Jiang Y, Zheng Y, Heng BC, Tian H, Ge Z* “Can Upregulation of Pluripotency Genes Enhance Stemness of Mesenchymal Stem Cells?” Stem Cell Reviews and Reports, (2021). [doi: 10.1007/s12015-021-10154-6]
  3. Zhu X, Chan Y, Yung SH, Tuan RS*, Jiang Y*. “Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis.” Frontiers in Cell and Developmental Biology, (2021). [doi: 10.3389/fcell.2020.607764]

2020

  1. Li K, Ning T, Wang H, Jiang Y, Zhang J, Ge Z*. “Nanosecond Pulsed Electric Fields Enhance Mesenchymal Stem Cells Differentiation via DNMT1 regulated OCT4/NANOG gene expression.” Stem Cell Research & Therapy, (2020). [doi: 10.1186/s13287-020-01821-5]
  2. Chen J, Huang Y, Yang J, Li K, Jiang Y, Heng BC, Cai Q*, Zhang J*, Ge Z*. “Multiple nanosecond pulsed electric fields stimulation with conductive poly(l-lactic acid)/carbon nanotubes films maintains the multipotency of mesenchymal stem cells during prolonged in vitro culture” Journal of Tissue Engineering and Regenerative Medicine, (2020). [doi: 10.1002/term.3088]
  3. Zhou Q, Cai Y*, Jiang Y, Lin X. “Exosomes in Osteoarthritis and Cartilage Injury: Advanced Development and Potential Therapeutic Strategies.”International Journal of Biological Sciences, 16(11):1811-1820 (2020). [doi: 7150/ijbs.41637]

2019

  1. Yang L, Tang C, Chen Y, Ruan D, Zhang E, Yin Z, Chen X, Jiang Y, Cai Y, Fei Y, Zhu S, Liu H, Hu J, Heng BC, Chen W, Shen W, Ouyang H. “Pharmacological Inhibition of Rac1 Activity Prevents Pathological Calcification and Enhances Tendon Regeneration.”ACS Biomaterials Science & Engineering, 5 (7):3511-3522 (2019). [doi: 1021/acsbiomaterials.9b00335]
  2. Li L, Jiang Y, Lin H, Shen H, Sohn J, Alexander PG, Tuan RS. “Muscle Injury Promotes Heterotopic Ossification by Stimulating Local Bone Morphogenetic protein-7 Production.”Journal of Orthopaedic Translation, 18:142-153 (2019). [doi: 1016/j.jot.2019.06.001]
  3. Jiang Y*, Tuan RS*. “Role of NGF/TrkA Signaling in Calcification of Articular Chondrocytes.” The FASEB Journal,33(9):10231-10239 (2019). [doi: 1096/fj.201900970]
  4. Sun J, Ma X, Chu HT, Feng B, Tuan RS, Jiang Y*. “Biomaterials and Advanced Biofabrication Techniques in hiPSCs Based Neuromyopathic Disease Modeling.” Front Bioeng Biotechnol, 29;7:373 (2019). [doi: 10.3389/fbioe.2019.00373]

2018 and before

  1. Huang L, Wang Y, Jiang Y, Wu Y, Hu C, Ouyang H. “High levels of GSK-3β signalling reduce osteogenic differentiation of stem cells in osteonecrosis of femoral head.” Journal of Biochemistry, 1;163(3):243-251 (2018). [doi: 1093/jb/mvx076]
  2. He J†, Jiang Y†, Alexander PG, Ulici V, Zhu Y, Wu S, Tuan RS. “Infrapatellar Fat Pad Aggravates Degeneration of Acute Traumatized Cartilage: A Possible Role for Interleukin-6.”Osteoarthritis and Cartilage, 25(1), 138-145 (2017). [doi: 1016/j.joca.2016.09.001]
  3. Zhou F, Zhang X, Cai D, Li J, Mu Q, Zhang W, Zhu S, Jiang Y, Shen W, Zhang S, Ouyang H. “Silk Fibroin-chondroitin Sulfate Scaffold with Immuno-inhibition Property for Articular Cartilage Repair.” Acta Biomaterialia, 63:64-75 (2017). [doi: 1016/j.actbio.2017.09.005]
  4. Jiang Y, Cai Y, Zhang W, Yin Z, Hu C, Tong T, Lu P, Zhang S, Neculai D, Tuan R, Ouyang H. “Human Cartilage Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration.” Stem Cells Translational Medicine, 5:1-12 (2016). [doi:10.5966/sctm.2015-0192] [#Remark: this work was specially reviewed and commented by the journal here; and the news has been covered by NSFC report here]
  5. Jiang Y, Hu C, Yu S, Yan J, Peng H, Ouyang HW, Tuan RS. “Cartilage Stem/Progenitor Cells Are Activated in Osteoarthritis via Interleukin-1β/Nerve Growth Factor Signaling.” Arthritis Research & Therapy, 17;17:327 (2015). [doi: 1186/s13075-015-0840-x]
  6. Jiang Y, Tuan R. “Origin and Function of Cartilage Stem/Progenitor Cells in Osteoarthritis.” Nature Reviews Rheumatology, 11(4):206-12 (2015). [doi:1038/nrrheum.2014.200]
  7. Xie X, Ulici V, Alexander PG, Jiang Y, Zhang C, Tuan RS. “Platelet-Rich Plasma Inhibits Mechanically Induced Injury in Chondrocytes.” Arthroscopy, 31(6):1142-50 (2015). [doi: 1016/j.arthro.2015.01.007]
  8. Zhang W, Heng BC, Jiang Y*, Ouyang HW*. “Clinical Translation of Autologous Cell-based Tissue Engineering Techniques as Class III Therapeutics in China: Taking Cartilage Tissue Engineering as An Example.” Journal of Orthopaedic Translation, 2(2):56-65 (2014). [doi: 1016/j.jot.2014.02.002]
  9. Jiang Y, Chen L, Zhang S, Tong T, Zhang W, Liu W, Xu G, Tuan RS, Heng BC, Crawford R, Xiao Y, Ouyang H. “Incorporation of Bioactive Polyvinylpyrrolidone-iodine within Bilayered Collagen Scaffolds Enhances the Differentiation and Subchondral Osteogenesis of Mesenchymal Stem Cells.” Acta Biomaterialia, 9(9):8089-98 (2013). [doi: 1016/j.actbio.2013.05.014]
  10. Zhang S, Jiang Y, Zhang W, Chen L, Tong T, Liu W, Mu Q, Liu H, Ji J, Ouyang H, Zou X. “Neonatal Desensitization Supports Long-term Survival and Functional Integration of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells in Rat Joint Cartilage Without Immunosuppression.” Stem Cells and Development, 22(1):90-101 (2013). [doi: 10.1089/scd.2012.0116]
  11. Zhang S, Chen L, Jiang Y, Cai Y, Xu G, Tong T, Zhang W, Wang L, Ji J, Shi P, Ouyang H. “Bi-layer Collagen/Microporous Electrospun Nanofiber Scaffold Improves the Osteochondral Regeneration”, Acta Biomaterialia, 9(7):7236-47 (2013). [doi: 1016/j.actbio.2013.04.003]
  12. Zhang W, Chen J, Tao J, Jiang Y, Hu C, Huang L, Ji J, Ouyang H. “The Use of Type 1 Collagen Scaffold Containing Stromal Cell-Derived Factor-1 to Create a Matrix Environment Conducive to Partial-thickness Cartilage Defects Repair.” Biomaterials, 34(3):713-23 (2013). [doi:1016/j.biomaterials.2012.10.027]
  13. Shi P, Jiang Y, Hu Z, Huang Y, Zhang J, Yu H, Zou X, Ouyang H. “Clinical Research and Application of Autologous Chondrocyte Implantation.” Chinese Journal of Orthopaedics, 32(1), 46-51 (2012). [doi: 10.3760/cma.j.issn.0253-2352.2012.01.008] [Remark: in Chinese, 中華骨科雜誌]
  14. Cai Y, Zhang G, Wang L, Jiang Y, Ouyang HW, Zou X. “Novel Biodegradable Three-dimensional Macroporous Scaffold Using Aligned Electrospun Nanofibrous Yarns for Bone Tissue Engineering. ” J Biomed Mater Res A, 100(5):1187-94 (2012). [doi: 1002/jbm.a.34063]
  15. Jiang L, Song X, Liu P, Zeng C, Huang Z, Zhu L, Jiang Y, Ouyang H, Hu H. “Platelet-mediated Mesenchymal Stem Cells Homing to the Lung Reduces Monocrotaline-induced Rat Pulmonary Hypertension. ” Cell Transplantation, 21(7):1463-75 (2012). [doi: 3727/096368912X640529]
  16. Jiang Y, Zhang S, Qi Y, Wang L, Ouyang H. “Cell Transplantation for Articular Cartilage Defects: Principles of Past, Present and Future Practice. ” Cell Transplantation, 20(5):593-607 (2011). [doi: 3727/096368910X532738]
  17. Jiang Y, Chen L, Zhu D, Zhang G, Qi Y, Ouyang H. “The Inductive Effect of Bone Morphogenetic Protein-4 on Chondral-lineage Differentiation and In Situ Cartilage Repair. ” Tissue Engineering Part A, 16(5):1621-32 (2010). [doi: 1089/ten.tea.2009.0681]
  18. Wang W, Li B, Li Y, Jiang Y, Ouyang H, Gao C. “In Vivo Restoration of Full-thickness Cartilage Defects by Poly(lactide-co-glycolide) Sponges Filled with Fibrin Gel, Bone Marrow Mesenchymal Stem Cells and DNA Complexes. ” Biomaterials 31(23):5953-65 (2010). [doi: 1016/j.biomaterials.2010.04.029]
  19. Wang W, Li B, Yang J, Xin L, Li Y, Yin H, Qi Y, Jiang Y, Ouyang H, Gao C. “The Restoration of Full-thickness Cartilage Defects with BMSCs and TGF-beta 1 Loaded PLGA/fibrin Gel Constructs. ” Biomaterials, 31(34):8964-73 (2010). [doi: 1016/j.biomaterials.2010.08.018]
  20. Zou X, Zhi Y, Chen X, Jin H, Wang L, Jiang Y, Yin Z, Ouyang H. “Mesenchymal Stem Cell Seeded Knitted Silk Sling for the Treatment of Stress Urinary Incontinence. “Biomaterials, 31(18):4872-9 (2010). [doi: 1016/j.biomaterials.2010.02.056]
  21. Zou X†, Jiang Y†, Zhang G, Jin H, Hieu NT, Ouyang H. “Specific Interactions Between Human Fibroblasts and Particular Chondroitin Sulfate Molecules for Wound Healing. ” Acta Biomaterialia 5(5):1588-95 (2009). [doi: 1016/j.actbio.2008.12.001]
  22. Qi Y, Chen X, Jiang Y, Cai H, Wang L, Hieu NT, Ouyang H. “Local Delivery of Autologous Platelet in Collagen Matrix Synergistically Stimulated In-situ Articular Cartilage Repair. ” Cell Transplantation, 18(10):1161-9 (2009). [doi: 3727/096368909X12483162197169]
  23. Zou X, Cai H, Yin Z, Chen X, Jiang Y, Hu H, Ouyang H. “A Novel Strategy Incorporating the Power of Mesenchymal Stem Cells into Allografts for Segmental Bone Tissue Engineering. ” Cell Transplantation, 18(4):433-41(2009).  [doi: 3727/096368909788809839]

Books Authored

  1. Li X, Zhu X, Sun J, Yung SH, Tuan RS, Jiang Y*. Chapter 4, ” Stem Cells and the Application in Orthopaedics.” In: Cui W, Zhao X, Liu S. (eds) Biofabrication for Orthopedics, Wiley-VCH, 2022. [doi: 10.1002/9783527831371.ch4]
  2. Jiang Y, Wang D, Block A, Tuan R. Chapter 49, ” Mesenchymal stem cells in musculoskeletal tissue engineering. ” In: Lanza R, Langer R, Vacanti JP, Atala A. (eds) Principles of Tissue Engineering, 5th Edition. 2020. [doi: 10.1016/B978-0-12-818422-6.00051-4]
  3. Jiang Y, Lin H, Tuan R. Chapter 1, “Overview- State of the Art and Future Prospectives of cartilage repair. ” In: Grässel/Aszódi. (eds) Cartilage-Volume 3: Repair Strategies and Regeneration, Springer, 2017. [doi: 10.1007/978-3-319-53316-2_1]
  1. Baker N, Jiang Y, Tuan R. “Mesenchymal Stem Cells and Regenerative Medicine. ” In: Michael J. H. Ratcliffe (eds), Encyclopedia of Immunobiology, 2016. [doi: 10.1016/B978-0-12-374279-7.15018-0]
  2. Lozito TP, Jiang Y, Tuan R. “Cartilage Healing, Repair, and Regeneration: Natural History to Current Therapies. ” In:Wilson-Rawls, Kusumi (eds), Innovations in Molecular Mechanisms and Tissue Engineering. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. Springer. [doi: 1/10.1007/978-3-319-44996-8_4]
  3. 歐陽宏偉，姜洋子，等， “軟骨組織工程”章節，醫學專業研究生國家級規劃教材《創傷、燒傷與再生醫學》第二版，第三版，人民衛生出版社，主編：付小兵， 2014, 2019. [ISBN13：9787117186506]
  4. Jiang Y, Tong T, Heng BC, Ouyang HW. “Cartilage Injuries: Role of Implantation of Human Stem/Progenitor Cells. ” In: Hayat M. (eds) Stem Cells and Cancer Stem Cells, Volume 3. Springer, Dordrecht 2012 [doi: 1007/978-94-007-2415-0_33]
  5. 姜洋子，歐陽宏偉，附錄： “組織工程產品標準及組織工程三類醫療新技術申報指南”，《再生醫學–基礎與臨床》, 人民衛生出版社, 主編：付小兵，2011. [ISBN： 978-7-117-16769-7]
  6. Zhang S, Jiang Y, Ouyang HW. “Cartilage Injuries of Women in Sports: The Present and Future Therapeutics. “International Journal of Medical and Biological Frontiers, 17(6), 595-610. 2011. [ISSN: 1081-3829]